How to Secure a Book Deal with a Publisher

In the past two months alone I've secured book deals for 6 authors. This past April, one of my authors secured a six-figure deal. Her book was sold in a bidding war and was bought by Simon & Schuster. 

I've discovered that there are two basic parts t

Self publishing vs Literary agent

If I self publish on Amazon, will a literary agent still accept my manuscript for consideration?